Prof. Moran Rubinstein

Prof. Moran Rubinstein is an Associate Professor at Tel Aviv University, affiliated with Gray Faculty of Medical & Health Sciences and the Sagol School of Neuroscience.

She completed her Ph.D. at Tel Aviv University in 2010 and conducted her postdoctoral training at the University of Washington in Seattle, USA, until 2015.

She established her research lab at Tel Aviv University in 2016 and was promoted to Associate Professor in 2024. Prof. Moran Rubinstein is an Associate Professor at Tel Aviv University, where she leads a research program focused on the neuronal and molecular basis of developmental and epileptic encephalopathies (DEEs).

Her work aims to uncover disease mechanisms and develop innovative, disease-modifying therapies for severe neurodevelopmental disorders. In collaboration with Prof. Eric Kremer (CNRS, France), she co-developed a novel viral-mediated gene therapy for Dravet syndrome, demonstrating efficacy in both juvenile and adult mouse models.

Prof. Rubinstein's lab also characterized new mouse models for GRIN2D- and CHD2-related DEEs, which faithfully recapitulate the multifaceted phenotypes observed in patients. These models serve as critical platforms for mechanistic studies and preclinical evaluation of targeted treatments.

Combining genetic, electrophysiological, and behavioral tools, her research seeks to bridge molecular neuronal changes with circuit-level and behavioral abnormalities. Her overarching goal is to translate mechanistic insights into transformative therapies for patients affected by rare developmental epilepsies.